Can CBD and alcohol be mixed?

CBD has gained popularity in recent years for its many properties, as it can help in reducing anxiety, relieving pain and improving sleep, among others.

At the same time, alcohol consumption is a socially ingrained practice in many cultures around the world. So, given the growing interest in CBD and its accessibility in the market, an important question arises: Is it safe to mix CBD and alcohol?

This combination raises equal parts curiosity and concern. While there are theories suggesting that CBD may mitigate some of the negative effects of alcohol, the lack of extensive research leaves unknowns about the possible interactions and side effects of the simultaneous consumption of the two.

This article delves into the complex world of CBD and alcohol, exploring what current science tells us about their combination, the effects it can have on the body and mind, and the precautions that should be taken.

Our aim is to provide clear, evidence-based guidance for those considering mixing these two substances, addressing the potential risks.


CBD-alcohol interactions: what the science says

Although scientific research is still at an emerging stage, some studies have begun to shed light on how these two substances may interact in the body.

Recent research suggests that CBD may exert neuroprotective effects, which could theoretically mitigate some of the harms associated with excessive alcohol consumption, such as neurodegeneration.

One study found that CBD attenuates alcohol-induced hepatic steatosis (fat accumulation in the liver), metabolic dysfunction and inflammation in mice, suggesting a therapeutic potential for CBD in the treatment of alcoholic liver disease¹.

The ability of CBD to influence alcohol intoxication and hangover symptoms has been studied. Some research indicates that CBD can reduce blood alcohol levels and improve post-consumption symptoms.

In particular, a systematic review of several studies on CBD as a candidate for pharmacotherapy of alcoholism and binge drinking highlights the neuroprotective effects of CBD against adverse consequences on the hippocampus, as well as its potential to reduce the need for further alcohol intake. CBD may therefore be a promising treatment for alcohol addiction².

However, despite the growing interest in CBD-alcohol interactions, it is crucial to approach this combination with caution. Another review, published in 2021, of multiple scientific investigations on CBD interactions with medicines, illicit substances and alcohol, highlights its potential to interact with a wide range of commonly used drugs, as well as with alcohol and tobacco³.

In conclusion, although there is growing interest and some preliminary evidence suggests that CBD may mitigate certain negative effects of alcohol, the science is still in the early stages.

The scientific community continues to investigate these interactions in order to provide recommendations based on solid evidence. Until then, consumers should proceed with caution, considering current knowledge and the recommendations of health professionals.

It should be noted that both substances are metabolised in the liver. In the same way that it is not good to take hangover medication because it overloads the liver, taking CBD mixed with alcohol could also have consequences, as the effects of this combination are not fully known, neither in the short term nor in the long term.

Therefore, we at The Tree CBD would like to remind you once again that CBD is not a medicine, nor does it replace any type of medical treatment. If you think you have a problem with alcohol, or could have a problem with alcohol, you should always consult a health professional or medical specialist and follow their recommendations.


  1. Wang, Y., Mukhopadhyay, P., Cao, Z., Wang, H., Feng, D., Haskó, G., … & Pacher, P. (2017). Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Scientific reports7(1), 12064.
  2. Turna, J., Syan, S. K., Frey, B. N., Rush, B., Costello, M. J., Weiss, M., & MacKillop, J. (2019). Cannabidiol as a novel candidate alcohol use disorder pharmacotherapy: a systematic review. Alcoholism: Clinical and Experimental Research43(4), 550-563.
  3. Balachandran, P., Elsohly, M., & Hill, K. P. (2021). Cannabidiol interactions with medications, illicit substances, and alcohol: a comprehensive review. Journal of general internal medicine36, 2074-2084.

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